The Minnesota Twins will look to win their 10th game in a row over the Chicago White Sox, including nine this season, when they meet in an American League Central matchup on Wednesday afternoon in Game 1 of a doubleheader. The twinbill was necessitated by Tuesday night's rain out. The Twins (52-39), who are 18-12 against divisional foes in 2024, are 36-31 against right-handed starting pitchers. The White Sox (26-67), who are just 7-24 vs. the AL Central, are 20-54 against righties. The projected starting pitchers are Bailey Ober (8-4, 4.12 ERA) for Minnesota and Erick Fedde (6-3, 3.13 ERA) for Chicago. 

First pitch from Guaranteed Rate Field in Chicago is set for 2:10 p.m. ET. Minnesota is a -164 favorite on the money line (risk $164 to win $100) in the latest Twins vs. White Sox odds from SportsLine consensus, while the total number of runs Vegas thinks will be scored, or the over/under, is 8. Before making any White Sox vs. Twins picks, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer simulation model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 16 of the 2024 MLB season a profitable 49-37 on all-top rated MLB picks this season. Dating back to last season, it is on a 24-9 roll on top-rated run-line picks (+1077). Anybody following has seen strong returns.

Now, the model has set its sights on Twins vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Now, here are several MLB odds and betting lines for White Sox vs. Twins:

  • Twins vs. White Sox money line: Minnesota -164, Chicago +137
  • Twins vs. White Sox over/under: 8 runs 
  • Twins vs. White Sox run line: Minnesota -1.5 (+100) 
  • MIN: The Twins have hit the money line in 45 of their last 71 games (+10.80 units) 
  • CWS: The White Sox have hit the game total under in 19 of their last 34 games at home (+3.95 units) 
  • Twins vs. White Sox picks: See picks at SportsLine

Why you should back the Twins

Second baseman Willi Castro has been on a roll of late, with two multi-hit games over the past three. In a 9-3 win over Houston on Saturday, Castro was 3-for-5 with a double, RBI and two runs scored. He was 2-for-6 in Monday's series-opening win at Chicago. In 91 games this season, he is batting .272 with 22 doubles, five triples, seven homers, 29 RBI and 54 runs scored.

Also helping power Minnesota is center fielder Byron Buxton. In 69 games this year, he is batting .282 with 18 doubles, three triples, nine homers, 38 RBI and 41 runs scored. He is 11-for-23 (.478) over the past six games. In Monday's victory over the White Sox, he was 3-for-5 with two doubles, one RBI and two runs scored. See which team to pick here.

Why you should back the White Sox

Fedde won his last outing, an 8-2 victory at Cleveland on July 3. In that game, he tossed six innings, allowing three hits, one earned run and three walks, while striking out three. He pitched against the Twins at Minnesota on April 23, receiving a no-decision. In that outing, he went six innings, allowing just three hits and one earned run with no walks and 11 strikeouts.

Offensively, first baseman Andrew Vaughn is among the White Sox's top hitters. In 85 games, he is batting .241 with 17 doubles, 11 homers, 43 RBI and 33 runs scored. He has hit safely in three consecutive games and in nine of the past 10. In the last series against Minnesota from April 29 to May 1, he was 5-for-13 (.385) with a double and two RBI in the three-game set. See which team to pick here

How to make Twins vs. White Sox picks

SportsLine's model is leaning over on the total, projecting nine combined runs. It also says one side of the money line has all the value. You can only get the MLB model's picks at SportsLine.

So who wins Twins vs. White Sox, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that's 49-37 on top-rated MLB picks, and find out.